Offensive ability should not target players at all?
Cures and buffs shoud not target Mobs ever?
This would take a number of possibilties out of the TAB list.
Or it should be like the old FF games where if you didn't pay attention you cast Cure on the mob, and when the mob used Confuse or some such on you you'd cast Fire II on your own Fighter.
I'd love it if the mobs had a good confuse spell that screwed up your targeting, and suddenly your lancer is stabbing you in the rear instead of the mob.