I have the same problem. I play in 1920x1080 on my 24" Samsung, and since I like having access to the rest of my computer I play in Windowed mode. In full screen the picture firs great, but the obvious drawback is the Alt+Tab crash.
In windowed mode, for some reason, the right side and bottom of the screen seem to "fall off" if you will. The right side isn't very noticeable, but on the bottom I had to move my exp bars up to be able to view them, which is fine except the status bar overlaps them and resets every time the game restarts to its original position. Definitely not a game breaking thing (as everything else works fine), but it is a minor annoyance.