I know it will save your setup per class, but can you save alternate versions per class as well? I was thinking one setup for soloing and one for grouping.
Not sure what control method/platform you use, but if you are using a controller, this is one of the beauties of it. You can set up to 8 different cross hotbars and either scroll through them with RB (R1 on PS3) or jump directly to one with RB + whatever the assigned face button for that hotbar is. It keeps the play space nice and clean and allows you to create sets of actions that you can easily switch to when appropriate, yet hide when they wouldn't be needed.Granted, it will only scroll through the hotbars with skills actually in them, so the first time you want to set one up, you'll have to switch to it manually (the second method mentioned above)
If you are using Mouse and Keyboard, I doubt there is an option for this, noticing most peoples cluttered UI's on YouTube vids (My god, how do people play like that? :P), but I could be wrong. Edited, Sep 12th 2013 8:49am by DragonBourne